Voluntary Participation Agreement

By oktober 14, 2021Geen categorie

In Nigeria, almost half of married women reported being invited by husbands to enroll in the hypertension study; No interviewees asked local seniors to participate in the study. The majority (94%, 617/655) of respondents, on both US and Nigerian sites, said participation was voluntary. Most (99%, 650/655) said they did not feel pressured to participate. In the United States, 97% (336/348) of respondents said they could withdraw, compared to 67% (206/307) in Nigeria (P <.0001). The adaptation to the time interval between consent to participate in the genetic study and our interview did not change the results of these analyses. In multi-prinalyt analyses, the regression coefficient remained significant for the site (β = − 2.602; SE [β] = .405, P < .0001) while this was not the case for the time interval (β = − 043, SE [β] = .069, P = .536). To investigate these hypotheses, we compared factors related to voluntary participation and understanding the purpose of studies between people participating in genetic epidemiological research on high blood pressure in an urban environment in the United States and in a rural town in Nigeria. Although comments (editorials and contributions) are abundant, this study is unique because it is the first large-scale cross-cultural empirical study of the voluntary participation and informed consent of people participating in similar genetic studies designed and implemented in an industrialized and resource-poor country. In addition, all participants were African-American or Nigerian. The design of our study included quantitative and qualitative methodological approaches. With 10% of respondents, in-depth interviews were conducted with audio recordings to examine the topics in more detail. The design of the survey tool was based on previous research on cultural issues related to consent to genetic research in Nigeria.42 The survey tool was pre-tested in the United States and Nigeria to confirm its accuracy in measuring participants` understanding of informed consent and decision-making regarding participation in genetic epidemiological studies.

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